Famotidine (INN) (pronounced: /fəˈmɒtɪdiːn/) is a histamine H₂-receptor antagonist that inhibits stomach acid production, and it is commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD). It is commonly marketed by J&J/Merck under the trade names Pepcidine and Pepcid. Unlike cimetidine, the first H₂ antagonist, famotidine has no effect on the cytochrome P450 enzyme system, and does not appear to interact with other drugs.

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